メタボリックエンジニアリングを通じて,植物のビタミンE含有量を高める
1Department of Biochemistry, Mail Stop 200, University of Nevada, Reno, NV 89557, USA.
まとめ
研究者らはガンマ・トコフェロールメチルトランスフェラーゼをクローン化して,植物におけるアルファ・トコフェロール (ビタミンE) の合成を強化した. これは,農業用オイルに含まれるアルファトコフェロールを増やすことにより,食事中のビタミンEレベルを高める可能性があります.
科学分野:
- バイオケミストリー バイオケミストリー
- 植物科学 植物科学について
- 栄養科学とは,栄養科学である.
背景:
- アルファトコフェロール (ビタミンE) は,ヒトの健康に不可欠な,脂質に溶ける重要な抗酸化物質です.
- 主要な食源である植物油は,アルファ・トコフェロルの前身であるガンマ・トコフェロールが豊富である.
- 現在のビタミンEの摂取量は,しばしば推奨値を下回っており,退行性疾患の増加と関連しています.
研究 の 目的:
- アルファ・トコフェロール生物合成の最終段階を担う酵素を特定し,クローン化します.
- 植物油におけるアルファ・トコフェロール含有量の増加の可能性を調査する.
主な方法:
- ゲノム学に基づくアプローチを使用して,ガンマ-トコフェロールメチルトランスフェラーゼ遺伝子を分離しました.
- アラビドプシスの種に遺伝子の過剰発現技術を使用して,トコフェロールの組成を変更しました.
主要な成果:
- ガンマ・トコフェロールメチルトランスフェラーゼ酵素をクローンに成功しました.
- アラビドプシス種子の酵素過剰発現は,種油におけるアルファ・トコフェロールの割合を大幅に増加させた.
- 油の組成の変化が示され,その前駆体よりもアルファトコフェロールを好む.
結論:
- ガンマトコフェロールメチルトランスフェラーゼは,植物におけるアルファトコフェロール合成の鍵となる酵素である.
- この酵素の遺伝子組み換えは,作物のビタミンEレベルを高めるための有効な戦略を提供します.
- 農業用油のアルファ・トコフェロールを増加させることで,人間の健康を改善するためにビタミンEの摂取量を改善することができます.
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