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Epacは,循環型AMPによって直接活性化されるRap1のグアニン核酸代謝因子です

J de Rooij1, F J Zwartkruis, M H Verheijen

  • 1Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands.

Nature
|December 16, 1998
PubMed
まとめ

研究者らは,循環型AMP (cAMP) によって直接活性化される新しいタンパク質であるEpacを発見しました. このグアニン・ヌクレオチド交換因子 (GEF) は,タンパク質キナーゼAとは独立してRap1の活性を調節し,新しいcAMPシグナル伝達経路を明らかにする.

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