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Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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カルシウムは,タンパク質キナーゼB経路のCaM-Kキナーゼ活性化を通じて細胞生存を促進する

S Yano1, H Tokumitsu, T R Soderling

  • 1Vollum Institute, Oregon Health Sciences University, Portland 97201, USA.

Nature
|December 22, 1998
PubMed
まとめ

カルシウムシグナル伝達は,Ca2+/カルモジュリン依存タンパク質キナーゼキナーゼ (CaM-KK) 経由でタンパク質キナーゼB (PKB) を活性化することによって,ニューロンをアポトーシスから保護します. この経路はBADをリン酸化し,プログラム細胞死を防止します.

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