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関連する概念動画

DNA Replication02:40

DNA Replication

DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication uses a large number of...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
The DNA Replication Fork01:02

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication forks, one in...
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
The DNA Replication Fork01:02

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication forks, one in...

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関連する実験動画

Updated: May 10, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

折りたたみDNAの研究

S Perlman, C Phillips, J O Bishop

    Cell
    |May 1, 1976
    PubMed
    まとめ
    この要約は機械生成です。

    ユーカリオットの核DNAには,折りたたみDNA,つまり,素早く複合体を形成する分子が含まれています. この研究では,折りたたみDNAが全ゲノムを表していることが明らかになり,クロスリンクではなく,イントラストランドの折りたたみを示唆しています.

    さらに関連する動画

    Folding and Characterization of a Bio-responsive Robot from DNA Origami
    07:59

    Folding and Characterization of a Bio-responsive Robot from DNA Origami

    Published on: December 3, 2015

    Studying DNA Looping by Single-Molecule FRET
    11:27

    Studying DNA Looping by Single-Molecule FRET

    Published on: June 28, 2014

    関連する実験動画

    Last Updated: May 10, 2026

    Analyzing and Building Nucleic Acid Structures with 3DNA
    16:24

    Analyzing and Building Nucleic Acid Structures with 3DNA

    Published on: April 26, 2013

    Folding and Characterization of a Bio-responsive Robot from DNA Origami
    07:59

    Folding and Characterization of a Bio-responsive Robot from DNA Origami

    Published on: December 3, 2015

    Studying DNA Looping by Single-Molecule FRET
    11:27

    Studying DNA Looping by Single-Molecule FRET

    Published on: June 28, 2014

    科学分野:

    • 分子生物学は分子生物学である.
    • 遺伝学 遺伝学とは
    • ユカリオットDNA構造 ユカリオットDNA構造

    背景:

    • ユーカリオット核DNAには,DNA濃度に関係なく,素早く二重複体を形成する分子が含まれています.
    • 折りたたみDNAと呼ばれるこの分子は,ヒドロキシラパチート吸附によって分離することができます.
    • 以前の研究では,ゲノム単位で,折り畳み回りの焦点の数が有限であることを示していた.

    研究 の 目的:

    • Xenopus laevis.の折りたたみDNAの性質とゲノム表現を調査する.
    • ランダムクロスリンクとイントラストランドの折りたたみを含む,折りたたみDNA形成に関する仮説を検証する.

    主な方法:

    • ランダムに切断され,制限エンドヌクレアースで消化されたXenopus laevisのDNAから折りたたみDNA分子の分離.
    • 孤立した折り畳み込み分子の配列内容の分析.
    • ランダムなDNAクロスリンクの仮説を検証する.

    主要な成果:

    • DNA全体の約10%を占める分離された折りたたみ分子は,Xenopus laevisのDNA配列全体を含んでいることが判明しました.
    • ランダムなDNAのクロスリンクは,観察された折りたたみDNA特性を説明するのに不十分でした.
    • 折りたたみDNA形成は,主にゲノム全体で変数サイトで発生するイントラストランド現象です.

    結論:

    • Xenopus laevisの折りたたみDNA形成は,主にイントラストランドプロセスである.
    • 観察された折りたたみDNA特性は,以前のモデルに異議を唱え,複雑な内ゲノム折りたたみメカニズムを示唆しています.
    • intrastrand foldback DNA形成の正確なメカニズムと機能的影響を明らかにするために,さらなる研究が必要です.