心筋梗塞後の死亡率と軽度から中等度のアルコール摂取量
J Muntwyler1, C H Hennekens, J E Buring
1Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Lancet (London, England)
|December 24, 1998
まとめ
軽度から中等度のアルコール摂取は,心臓発作歴のある男性における全死亡率の低下と関連しています. この研究は,この患者グループにおける控えめな飲酒の潜在的な保護効果を示唆しています.
科学分野:
- 心血管の健康について
- エピデミオロジー エピデミオロジー
- アルコール研究 アルコール研究
背景:
- 過剰なアルコール摂取は死亡率の増加と関連しています.
- 軽度から中等度のアルコールの摂取は,健康な個人の死亡率を低下させる可能性があります.
- 心筋梗塞後の患者の死亡率に対するアルコールの影響に関するデータは限られている.
研究 の 目的:
- 軽度から中等度のアルコール摂取と,前回の心筋梗塞を患った男性における死亡率との関係を調査する.
- この特定の患者集団におけるデータの不足に対処するためです.
主な方法:
- 医師の健康研究から90,150人の男性を対象とした前向きな研究.
- 前回の心筋梗塞と,がん,脳卒中,または肝臓疾患の既往歴のない男性5,358人を含む.
- アルコールの消費量は,食品頻度アンケートを使用して推定されています.
主要な成果:
- 平均5年間の追跡調査で,920人の死亡が観察されました.
- 適度なアルコール摂取は,混同因子調整後の総死亡率 (p=0.016) の有意な低下を示した.
- 総死亡率に対する相対リスクは,適度なアルコール摂取量 (例えば,週に2〜4杯で0.72) を増加させると減少した.
結論:
- 前回の心筋梗塞を患った男性で,少量から中程度の量のアルコールを摂取すると,全死亡率が低下します.
- 発見は,このコホートにおける軽度から適度なアルコール摂取による潜在的生存利益を示唆しています.
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