冠動脈性心疾患の逆転のための集中的なライフスタイルの変化
D Ornish1, L W Scherwitz, J H Billings
1Department of Medicine, California Pacific Medical Center, San Francisco, USA. DeanOrnish@aol.com
JAMA
|December 24, 1998
まとめ
集中的なライフスタイルの変化が5年間で冠動脈動脈硬化症を大幅に後退させ,通常のケアと比較して心臓イベントが少なくなりました. 患者はこれらの心臓に健康的な習慣を維持し,長期的な実現可能性と利益を示しました.
科学分野:
- 心血管医学 心血管医学
- 予防性心臓病学 予防性心臓病学
- ライフスタイル 医療
背景:
- ライフスタイル・ハート・トライアルでは,集中的なライフスタイルの変化が1年で冠動脈動脈硬化症を逆転させることが示されました.
- これらの変化を長期にわたって維持することは,以前は確立されていなかった.
研究 の 目的:
- 5年間,集中的なライフスタイルの変化を維持する可能性を評価する.
- 脂質低下薬なしで冠動脈疾患の進行に対するこれらの変化の影響を評価する.
主な方法:
- 冠動脈疾患の48人の患者を対象としたランダム化制御試験です.
- 1グループは,5年間,集中的なライフスタイル変更 (食事,運動,ストレス管理,禁煙,サポート) を受けました.
- 対照群は通常のケアを受け,フォローアップには定量冠動脈動脈撮影を用いた.
主要な成果:
- 集中生活習慣群の患者は,5年後,冠動脈狭窄の7.9%の相対的な改善を示し,変化を維持しました.
- 対照群では,狭窄症の相対的な悪化が27.7% (P=.001) であった.
- 集中治療群は,5年間で心臓発作が有意に少なかった (25対45).
結論:
- 集中的なライフスタイルの介入は,冠動脈動脈硬化症の持続的な後退を促進します.
- これらのライフスタイルの変更は5年間実行可能であり,心臓のイベントを減らすことができます.
- 冠動脈動脈硬化症の進行は,通常のケアグループとは異なり,停止し,逆転しました.
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