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Updated: Aug 4, 2026

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

融合能力のあるワクチン:HIVの原発単離体の広範な中和

R A LaCasse1, K E Follis, M Trahey

  • 1The Montana Biotechnology Center and Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.

Science (New York, N.Y.)
|January 15, 1999
PubMed
まとめ

新しいHIVワクチンの免疫遺伝子は,ウイルスの融合構造を捕捉し,24の患者単離のうち23に対して,広範に中和する抗体を誘発します. このアプローチは,より効果的なヒト免疫不全ウイルス (HIV) ワクチンの開発につながる可能性があります.

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Overview
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Immune Response Against Viral Pathogens

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NK Cells
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Cancer Vaccines

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Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
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Poliomyelitis

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Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...