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Updated: Aug 1, 2026

Coupled Assays for Monitoring Protein Refolding in Saccharomyces cerevisiae
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タンパク質の翻訳と折り畳みは,エンドプラズマ網膜に居住するキナーゼによって結合されます

H P Harding1, Y Zhang, D Ron

  • 1Skirball Institute of Biomolecular Medicine, Department of Medicine, NYU School of Medicine, New York 10016, USA.

Nature
|February 4, 1999
PubMed
まとめ

エンドプラズマ網膜 (ER) のストレスは,タンパク質合成を減少させる経路を誘発する. 新たに特定されたPERKという遺伝子は,エウカリオット開始因子-2alpha (eIF2alpha) をリン酸化し,ERストレス中に翻訳を弱めるタンパク質キナーゼをコードする.

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