現在のおよび遠隔の血圧と認知機能の低下
R J Glynn1, L A Beckett, L E Hebert
1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02215, USA. rglynn@rics.bwh.harvard.edu
JAMA
|February 10, 1999
まとめ
中年の血圧は,高齢者の認知機能低下を線形的に予測するものではありません. しかし,シストリック血圧が上昇すると,認知テストの誤差率が増加することを示す複雑な関係が存在します.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 心血管の健康についてです.
- 神経科学は神経科学である.
背景:
- 以前の研究は,中年の血圧と後の認知機能低下との潜在的な関連を示唆しています.
- この関係を理解することは,高齢者集団における認知障害の予防戦略を策定する上で極めて重要です.
研究 の 目的:
- 高齢者における血圧 (BP) と認知機能のレベル,および変化との関連を将来的に調査する.
- 心血管の健康と認知老化との複雑な相互作用を明らかにする.
主な方法:
- 高齢者の流行病学研究 (EPESE) の確立された人口と高血圧検出およびフォローアッププログラム (HDFP) の東ボストン構成要素のデータを利用した縦断型,人口ベースの研究.
- 認知機能は,ショートポータブルメンタルステータスアンケートとイーストボストン記憶テストを使用して6年間にわたって評価されました.
- 血圧は,ベースラインとベースライン評価の9年前に測定されました.
主要な成果:
- 血圧と認知機能,または時間の経過による変化との間に強い線形的な関連性は見つかりませんでした.
- ベースラインより9年前におけるシストリック血圧の上昇 (>または=160mmHg) は,精神状態アンケート誤差率の14%の増加と関連していました.
- 静脈動脈と静脈動脈動脈の血圧は,認知的エラーとU形の関連性を示し,基準グループと比較して,低血圧と高血圧の両方のレベルでのエラーの増加を示した.
結論:
- 研究結果は,高齢者の血圧と認知機能の低下との間の単純な線形的な関係を支持していません.
- この結果は,これまで考えられていたよりも,血圧と認知機能との間にはより複雑な関係があることを示唆している.
- 加えて,老化におけるBPと認知の関係を裏付ける複雑なメカニズムを完全に解明するためにさらなる研究が必要である.
関連する概念動画
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Physiological Factors:
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Several factors...
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Preparation:
Preparation:
