哺乳類における雌の発達は,Wnt-4シグナル伝達によって調節される

S Vainio¹, M Heikkilä, A Kispert

¹Department of Molecular and Cellular Biology, The BioLabs, Harvard University, Cambridge, Massachusetts 02138, USA.

Nature

|February 16, 1999

まとめ

Wnt-4シグナリング分子は,哺乳類の雌性性発達に不可欠である. その欠如は,ムレリアン管の形成を妨害し,雄のウルフィアン管の発達を促進することによって,雌の男性化につながる.

科学分野:

発達生物学発達生物学について
遺伝学遺伝学とは
エンドクリノロジーエンドクリノロジー

背景:

哺乳類の胚は,最初は性的に無関心であり,性特異的な発達のためにホルモン信号を必要とします.
ミュレリアン阻害物質やテストステロンのような重要なホルモンは,生殖管の分化に直接作用する.
Wnt-4シグナリング分子は,女性の性発達において重要な役割を果たします.

研究の目的:

哺乳類の性発達におけるWnt-4の役割を調査する.
Wnt-4変異が生殖器形成とホルモンシグナル伝達に及ぼす影響を理解する.

主な方法:

Wnt-4変異マウスモデルの分析.
生殖管の発達の検査 (ミュレリアンとウルフィアン).
レイディグ細胞の発達とテストステロン生物合成の評価.

主要な成果:

Wnt-4は,男女ともにムレリアン管の形成に不可欠です.
女性のWnt-4欠乏症は男性化につながり,ムレリアン管が欠け,ウルフィアン管が発達する.
発達中の卵巣におけるWnt-4は,レイディグ細胞の発達を抑制し,Wnt-4変異体の雌の子宮外テストステロン産生を防ぐ.

結論:

Wnt-4は,女性の性二形態の確立に不可欠です.
Wnt-4信号伝達の障害は,女性の男性特性の不適切な発達につながる可能性があります.
性二形態は,Wnt-4を含む局所的および全身的信号の複雑な相互作用によって調節されます.

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