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rabindra.tharu.np@gmail.com
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Increased beta synchronization underlies perception-action hyperbinding in functional movement disorders
Functional movement disorders are amongst the most common and disabling neurological conditions, placing a significant burden on the healthcare system. Despite the frequency and importance of functional movement disorders, our understanding of the underlying pathophysiology is limited, hindering the development of causal treatment options. Traditionally, functional movement disorders were considered as a psychiatric condition, associated…
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rabindra.tharu.np@gmail.com
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Patterns of cortical thickness alterations in degenerative cervical myelopathy: associations with dexterity and gait dysfunctions
Degenerative cervical myelopathy (DCM) can lead to significant brain structural reorganization. The association between the cortical changes and specific motor symptoms in DCM has yet to be fully elucidated. We investigated the associations between cortical thickness changes with neurological symptoms, such as dexterity and gait abnormalities, in patients with DCM in a case-control study. A…
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rabindra.tharu.np@gmail.com
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Ground-truth validation of uni- and multivariate lesion inference approaches
Lesion analysis aims to reveal the causal contributions of brain regions to brain functions. Various strategies have been used for such lesion inferences. These approaches can be broadly categorized as univariate or multivariate methods. Here we analysed data from 581 patients with acute ischaemic injury, parcellated into 41 Brodmann areas, and systematically investigated the inferences…
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rabindra.tharu.np@gmail.com
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Colchicine treatment in amyotrophic lateral sclerosis: safety, biological and clinical effects in a randomized clinical trial
In preclinical studies, the anti-inflammatory drug colchicine, which has never been tested in amyotrophic lateral sclerosis, enhanced the expression of autophagy factors and inhibited accumulation of transactive response DNA-binding protein 43 kDa, a known histopathological marker of amyotrophic lateral sclerosis. This multicentre, randomized, double-blind trial enrolled patients with probable or definite amyotrophic lateral sclerosis who experienced…
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rabindra.tharu.np@gmail.com
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Understanding the mechanisms of fatigue in multiple sclerosis: linking interoception, metacognition and white matter dysconnectivity
One of the most prominent symptoms in multiple sclerosis is pathological fatigue, often described by sufferers as one of the most debilitating symptoms, affecting quality of life and employment. However, the mechanisms of both, physical and cognitive fatigue in multiple sclerosis remain elusive. Here, we use behavioural tasks and quantitative MRI to investigate the neural…
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rabindra.tharu.np@gmail.com
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Interictal intracranial EEG asymmetry lateralizes temporal lobe epilepsy
Patients with drug-resistant temporal lobe epilepsy often undergo intracranial EEG recording to capture multiple seizures in order to lateralize the seizure onset zone. This process is associated with morbidity and often ends in postoperative seizure recurrence. Abundant interictal (between-seizure) data are captured during this process, but these data currently play a small role in surgical…
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rabindra.tharu.np@gmail.com
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Freezing of gait in Parkinson’s disease is related to imbalanced stopping-related cortical activity
Freezing of gait, characterized by involuntary interruptions of walking, is a debilitating motor symptom of Parkinson’s disease that restricts people’s autonomy. Previous brain imaging studies investigating the mechanisms underlying freezing were restricted to scan people in supine positions and yielded conflicting theories regarding the role of the supplementary motor area and other cortical regions. We…
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rabindra.tharu.np@gmail.com
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Intranasal administration of trehalose reduces α-synuclein oligomers and accelerates α-synuclein aggregation
Abnormal α-synuclein (αSyn), including an oligomeric form of αSyn, accumulates and causes neuronal dysfunction in the brains of patients with multiple system atrophy. Neuroprotective drugs that target abnormal αSyn aggregation have not been developed for the treatment of multiple system atrophy. In addition, treating diseases at an early stage is crucial to halting the progress…
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rabindra.tharu.np@gmail.com
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Data-driven retrieval of population-level EEG features and their role in neurodegenerative diseases
Electrophysiologic disturbances due to neurodegenerative disorders such as Alzheimer’s disease and Lewy Body disease are detectable by scalp EEG and can serve as a functional measure of disease severity. Traditional quantitative methods of EEG analysis often require an a-priori selection of clinically meaningful EEG features and are susceptible to bias, limiting the clinical utility of…
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rabindra.tharu.np@gmail.com
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Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data
Participant motion in brain magnetic resonance imaging is associated with processing problems including potentially non-useable/incomplete data. This has implications for representativeness in research. Few large studies have investigated predictors of increased motion in the first instance. We exploratively tested for association between multiple psychological and physical health traits with concurrent motion during T structural, diffusion,…
