-
rabindra.tharu.np@gmail.com
·
An egg-sabotaging mechanism drives non-Mendelian transmission in mice
Selfish genetic elements drive in meiosis to distort their transmission ratio and increase their representation in gametes, violating Mendel’s law of segregation. The two established paradigms for meiotic drive, gamete killing and biased segregation, are fundamentally different. In gamete killing, typically observed with male meiosis, selfish elements sabotage gametes that do not contain them. By…
-
rabindra.tharu.np@gmail.com
·
Modulation of a critical period for motor development in Drosophila by BK potassium channels
Critical periods are windows of heightened plasticity occurring during neurodevelopment. Alterations in neural activity during these periods can cause long-lasting changes in the structure, connectivity, and intrinsic excitability of neurons, which may contribute to the pathology of neurodevelopmental disorders. However, endogenous regulators of critical periods remain poorly defined. Here, we study this issue using a…
-
rabindra.tharu.np@gmail.com
·
Flies tune the activity of their multifunctional gyroscope
Members of the order Diptera, the true flies, are among the most maneuverable flying animals. These aerial capabilities are partially attributed to flies’ possession of halteres, tiny club-shaped structures that evolved from the hindwings and play a crucial role in flight control. Halteres are renowned for acting as biological gyroscopes that rapidly detect rotational perturbations…
-
rabindra.tharu.np@gmail.com
·
Development of neural circuits for social motion perception in schooling fish
The collective behavior of animal groups emerges from the interactions among individuals. These social interactions produce the coordinated movements of bird flocks and fish schools, but little is known about their developmental emergence and neurobiological foundations. By characterizing the visually based schooling behavior of the micro glassfish Danionella cerebrum, we found that social development progresses…
-
rabindra.tharu.np@gmail.com
·
E-cadherin tunes tissue mechanical behavior before and during morphogenetic tissue flows
Adhesion between epithelial cells enables the remarkable mechanical behavior of epithelial tissues during morphogenesis. However, it remains unclear how cell-cell adhesion influences mechanics in both static and dynamically flowing confluent epithelial tissues. Here, we systematically modulate E-cadherin-mediated adhesion in the Drosophila embryo and study the effects on the mechanical behavior of the germband epithelium before…
-
rabindra.tharu.np@gmail.com
·
Orbitofrontal cortex modulates auditory cortical sensitivity and sound perception in Mongolian gerbils
Sensory perception is dynamic, quickly adapting to sudden shifts in environmental or behavioral context. Although decades of work have established that these dynamics are mediated by rapid fluctuations in sensory cortical activity, we have a limited understanding of the brain regions and pathways that orchestrate these changes. Neurons in the orbitofrontal cortex (OFC) encode contextual…
-
rabindra.tharu.np@gmail.com
·
Episodic-like memory in wild free-living blue tits and great tits
Episodic-like memory in non-human animals represents the behavioral characteristics of human episodic memory-the ability to mentally travel backward in time to “re-live” past experiences. A focus on traditional model species of episodic-like memory may overlook taxa possessing this cognitive ability and consequently its evolution across species. Experiments conducted in the wild have the potential to…
-
rabindra.tharu.np@gmail.com
·
C. elegans touch receptor neurons direct mechanosensory complex organization via repurposing conserved basal lamina proteins
The sense of touch is conferred by the conjoint function of somatosensory neurons and skin cells. These cells meet across a gap filled by a basal lamina, an ancient structure found in metazoans. Using Caenorhabditis elegans, we investigate the composition and ultrastructure of the extracellular matrix at the epidermis and touch receptor neuron (TRN) interface.…
-
rabindra.tharu.np@gmail.com
·
Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice
Basolateral amygdala (BLA) is a key hub for affect in the brain, and dysfunction within this area contributes to a host of psychiatric disorders. BLA is extensively and reciprocally interconnected with frontal cortex, and some aspects of its function are evolutionarily conserved across rodents, anthropoid primates, and humans. Neuron density in BLA is substantially lower…
