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rabindra.tharu.np@gmail.com
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Combining early lower eyelid surgery with neuromuscular retraining for synkinesis prevention after facial palsy: the role of the eye in aberrant facial nerve regeneration
BACKGROUND Facial synkinesis (FS) is a distressing sequela of facial palsy (FP) characterized by involuntary, simultaneous movements of facial muscles occurring during voluntary facial expressions. Treatment of synkinesis is challenging, and preventive methods are needed. AIM This study evaluated the efficacy of physical facial nerve rehabilitation (PFNR) therapy alone vs. PNFR with eyelid surgery to…
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rabindra.tharu.np@gmail.com
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Dominating Alzheimer’s disease diagnosis with deep learning on sMRI and DTI-MD
BACKGROUND Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disorder that has become one of the major health concerns for the elderly. Computer-aided AD diagnosis can assist doctors in quickly and accurately determining patients’ severity and affected regions. METHODS In this paper, we propose a method called MADNet for computer-aided AD diagnosis using multimodal…
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rabindra.tharu.np@gmail.com
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Isoflurane conditioning improves functional outcomes after peripheral nerve injury in a sciatic cut repair murine model
INTRODUCTION Anesthetic conditioning has been shown to provide neuroprotection in several neurological disorders. Whether anesthetic conditioning provides protection against peripheral nerve injuries remains unknown. The aim of our current study is to investigate the impact of isoflurane conditioning on the functional outcomes after peripheral nerve injury (PNI) in a rodent sciatic nerve injury model. METHODS…
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rabindra.tharu.np@gmail.com
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Effectiveness of acupuncture in treating patients with pain and mental health concerns: the results of the Alberta Complementary Health Integration Project
BACKGROUND This study presents real-world evidence on the clinical outcomes of the Alberta Complementary Health Integration Project (ABCHIP), which utilized acupuncture to address pain and mental health issues in two vulnerable populations in Alberta: youth (aged 24 and below) and elderly (aged 55 and above). METHODS Over 282 days, a total of 606 patients received 5,424…
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rabindra.tharu.np@gmail.com
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Impact of a passive upper-body exoskeleton on muscular activity and precision in overhead single and dual tasks: an explorative randomized crossover study
INTRODUCTION Tasks performed at or above head height in industrial workplaces pose a significant challenge due to their association with musculoskeletal disorders. Upper-body exoskeletons have been identified as a potential solution for mitigating musculoskeletal loads and fighting against excessive muscular fatigue. However, the influence of such support on fine motor control, as well as on…
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rabindra.tharu.np@gmail.com
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Relationship between carotid atherosclerosis and lipoprotein (a) in patients with acute ischemic stroke
OBJECTIVE This study aimed to examine the relationship between lipoprotein (a) (Lp[a]) and other blood lipid indexes and carotid artery atherosclerosis in patients with acute ischemic stroke (AIS). METHODS A total of 2,018 patients were selected from the hospital “acute stroke intervention and secondary prevention registration database” by identifying blood fat indexes (cholesterol, triglyceride, high-density…
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rabindra.tharu.np@gmail.com
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Assessment tools for cognitive performance in Parkinson’s disease and its genetic contributors
BACKGROUND We have shown that genetic factors associating with motor progression of Parkinson’s disease (PD), but their roles in cognitive function is poorly understood. One reason is that while cognitive performance in PD can be evaluated by various cognitive scales, there is no definitive guide indicating which tool performs better. METHODS Data were obtained from…
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rabindra.tharu.np@gmail.com
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Effects of buccal acupuncture on postoperative analgesia in elderly patients undergoing laparoscopic radical gastrectomy: a randomized controlled trial
OBJECTIVE This study aimed to evaluate the efficacy and safety of buccal acupuncture on postoperative analgesia, perioperative stress response and adverse events in elderly patients undergoing laparoscopic radical gastrectomy. METHODS It was a prospective, outcome assessor-blinded, randomized controlled trial, involving 90 patients aged 65-80 years who were treated with an elective laparoscopic radical gastrectomy. They were…
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rabindra.tharu.np@gmail.com
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Time from injury to acute surgery for patients with traumatic cervical spinal cord injury in South-East Norway
BACKGROUND The recommended treatment for cervical spinal cord injury (cSCI) is surgical decompression and stabilization within 24 h after injury. The aims of the study were to estimate our institutional compliance with this recommendation and identify potential factors associated with surgical delay. METHODS Population-based retrospective database study of patients operated for cSCI in 2015-2022 within the…
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rabindra.tharu.np@gmail.com
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Prospective cohort study evaluating efficacy and safety of efgartigimod in Chinese generalized myasthenia gravis patients
BACKGROUND Despite the efficacy of efgartigimod demonstrated in ADAPT phase 3 trial, data specifically derived from Chinese participants are not available. Therefore, we aimed to evaluate the efficacy and safety of efgartigimod in Chinese patients with generalized myasthenia gravis (gMG). METHODS This is a prospective cohort study conducted in 8 hospitals across China. gMG patients…
