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rabindra.tharu.np@gmail.com
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Sexual dimorphism in the structural colours of the wings of the black soldier fly (BSF) Hermetia illucens (Diptera: Stratiomyidae)
The black soldier fly (BSF) Hermetia illucens (Diptera: Stratiomyidae) plays a significant role at the larval stage in the circular economy due to its ability to convert organic waste into valuable products for energy, food, feed, and agricultural applications. Many data are available on larval development and biomass generation, but basic research on this species…
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rabindra.tharu.np@gmail.com
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Metabolites profiling, in-vitro and molecular docking studies of five legume seeds for Alzheimer’s disease
Even though legumes are valuable medicinal plants with edible seeds that are extensively consumed worldwide, there is little information available on the metabolic variations between different dietary beans and their influence as potential anti-cholinesterase agents. High-resolution liquid chromatography coupled with mass spectrometry in positive and negative ionization modes combined with multivariate analysis were used to…
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rabindra.tharu.np@gmail.com
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Machine learning developed a macrophage signature for predicting prognosis, immune infiltration and immunotherapy features in head and neck squamous cell carcinoma
Macrophages played an important role in the progression and treatment of head and neck squamous cell carcinoma (HNSCC). We employed weighted gene co-expression network analysis (WGCNA) to identify macrophage-related genes (MRGs) and classify patients with HNSCC into two distinct subtypes. A macrophage-related risk signature (MRS) model, comprising nine genes: IGF2BP2, PPP1R14C, SLC7A5, KRT9, RAC2, NTN4,…
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rabindra.tharu.np@gmail.com
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Going beyond hardware limitations with advanced stray light calibration for the Metop-3MI space instrument
Space optical instruments play a pivotal role in enhancing our understanding of the universe and our planet, and are crucial in addressing the urgent challenges posed by climate change. In this context, stray light has emerged as a primary performance limitation. Originating from ghost reflections or scattering, it obscures essential details and introduces false information…
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rabindra.tharu.np@gmail.com
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Enhancing response inhibition behavior through tDCS intervention in college students with smartphone addiction
Smartphone addiction, emerging from excessive use of smartphones, poses a challenge to inhibitory control functions within society. This research employed transcranial direct current stimulation (tDCS) as an intervention alongside the stop signal task (SST) to explore behavioral distinctions between individuals with smartphone addiction and a non-addicted control group, focusing on the efficacy of tDCS intervention.…
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rabindra.tharu.np@gmail.com
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Circulating endocannabinoid levels in SARS-CoV-2 infection and their potential role in the inflammatory response
Plasma levels of endocannabinoids (eCBs) are very dynamic and variable in different circumstances and pathologies. The aim of the study was to determine the levels of the main eCBs and N-acylethanolamines (NAEs) in COVID-19 patients during the acute and post-acute phase of SARS-CoV-2 infection. Samples collected before December 31, 2020 were used for the determination of…
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rabindra.tharu.np@gmail.com
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Exploration of the factors affecting different delirium subtypes in hospitalized COVID-19 patients: a multicentre cross-sectional study
During the COVID-19 pandemic, delirium became a major complication that worsened patient outcomes. However, the factors influencing the severity of delirium in patients with COVID-19 have not been determined. We conducted this study to detect influencing factors associated with subtypes of delirium in patients with COVID-19. We included 1774 adult inpatients with COVID-19 from January…
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rabindra.tharu.np@gmail.com
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Preparation of self-preserving personal care cosmetic products using multifunctional ingredients and other cosmetic ingredients
The development of self-preserving personal care cosmetics represents a significant advancement in the cosmetics industry, offering safer and more natural alternatives to consumers. This study focused on the preparation of such formulations using multifunctional ingredients along with other cosmetic components. Five unique multifunctional ingredients (MFIs) were identified based on their antimicrobial properties: sodium coco PG-dimonium…
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rabindra.tharu.np@gmail.com
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Neural mechanisms responsible for vagus nerve stimulation-dependent enhancement of somatosensory recovery
Impairments in somatosensory function are a common and often debilitating consequence of neurological injury, with few effective interventions. Building on success in rehabilitation for motor dysfunction, the delivery of vagus nerve stimulation (VNS) combined with tactile rehabilitation has emerged as a potential approach to enhance recovery of somatosensation. In order to maximize the effectiveness of…
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rabindra.tharu.np@gmail.com
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Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses
The druggable proteome refers to proteins that can bind to small molecules with appropriate chemical affinity, inducing a favorable clinical response. Predicting druggable proteins through screening and in silico modeling is imperative for drug design. To contribute to this field, we developed an accurate predictive classifier for druggable cancer-driving proteins using amino acid composition descriptors…
