Analytical chemistry research underpins the measurement and characterization of chemical substances across environmental, biological, pharmaceutical, and materials contexts. It advances accuracy, sensitivity, and reproducibility through method development, validation, and standardization, enabling confident decision‑making and translation to practice. JoVE Visualize supports this area by pairing relevant PubMed articles with JoVE experiment videos to clarify complex procedures and workflows.
Key Methods & Emerging Trends
Established Methods in Analytical Chemistry
Core approaches include chromatography (GC, HPLC), mass spectrometry, spectroscopy (UV‑Vis, IR, NMR), electroanalytical techniques, and sample preparation strategies such as extraction and derivatization. These methods quantify analytes, elucidate structures, and assess purity and stability across diverse matrices.
Innovative Approaches and Emerging Trends
Recent advances feature hyphenated techniques (LC‑MS/MS, GC‑MS), ambient ionization MS, microfluidics and lab‑on‑a‑chip, high‑resolution mass analyzers, and chemometrics with machine learning for pattern discovery and prediction. Green analytical chemistry and automation improve throughput and sustainability. JoVE experiment videos illuminate protocols, instrumentation setup, and data interpretation.