冠心病和铁状况:前性研究的元分析
1Clinical Trial Service Unit, Nuffield Department of Clinical Medicine, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK. john.danesh@balliol.ox.ac.uk
Circulation
|February 23, 1999
概括
这次元分析没有发现强有力的证据表明铁状况标志物如血清费里丁或转林和与冠心病 (CHD) 风险有关. 需要进一步的研究来澄清任何潜在的关联.
科学领域:
- 心血管流行病学心血管流行病学
- 营养科学 营养科学
- 生物标志物 生物标志物
背景情况:
- 关于铁状况与冠心病 (CHD) 之间的关联存在相互矛盾的结果.
- 未来的流行病学研究已经研究了这种关系,结果各不相同.
研究的目的:
- 量化评估铁状况标志物与心血管疾病风险之间的流行病学关联.
- 通过系统性审查和元分析,综合多项前性研究的发现.
主要方法:
- 发表的前性研究的系统审查和元分析.
- 包括报告铁状况标记物的研究 (血清费里丁,转激素和等). 和心血管疾病发病率.
- 研究特征的抽象,混调整和风险估计.
主要成果:
- 分析了12项涉及7800例心血管疾病病例的研究.
- 血清费里丁没有发现任何显著的关联 (RR 1.0,95% CI 0.8-1.3).
- 转林和率 (RR 0.9,95% CI 0.7-1.1),总结铁能力,血清铁和食铁也显示出不显著的风险比率.
结论:
- 目前公布的前性研究缺乏强有力的证据,证明铁状况与冠状动脉疾病之间存在强烈的流行病学联系.
- 现有的数据不支持常见铁生物标志物与心血管风险之间的显著关联.
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