在患有不稳定性胸痛的患者中,在出院时C反应性蛋白的水平升高预测了复发的不稳定性
L M Biasucci1, G Liuzzo, R L Grillo
1Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy. biasucci@pelagus.it
Circulation
|February 23, 1999
概括
在不稳定的心痛释放后,C-反应蛋白 (CRP) 的持续升高表明复发不稳定的风险更高. 这种标志物可能持续数月,与克拉米迪亚肺炎感染有关.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 炎症 炎症是一种炎症.
背景情况:
- 不稳定的胸痛是一种危急的心血管疾病.
- 评估放出后的炎症标志物对于风险分层至关重要.
研究的目的:
- 为了确定是否C-反应性蛋白 (CRP) 水平在不稳定的心脏病患者在出院时保持升高.
- 调查持续的CRP升高和复发性心血管事件之间的关联.
主要方法:
- 在53名不稳定的胸痛患者中测量了CRP,SAA,纤维素,胆固醇和对H. pylori和C. pneumoniae的抗体.
- 在入院,出院和出院后3个月收集血液样本.
- 随访患者1年来跟踪重新入院的不稳定性或心肌梗塞.
主要成果:
- 49%的患者在出院时CRP升高 (>3 mg/L).
- 升高的CRP释放与更高的再接收率 (69%对15%) 有显著的关联.
- 较高的CRP水平与复发性不稳定性风险增加相关,并与C. pneumoniae标位有关.
结论:
- 不稳定性胸痛后CRP升高表明正在进行的炎症,并预测反复出现的不稳定性.
- 持续的炎症,可能与慢性感染有关,如C.肺炎,可能是亚临床不稳定的标志.
- 血清粉样蛋白和血清粉样蛋白是不稳定性 angina 的有价值的预后标志物.
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