来自东南亚的成年人中的胺缺乏和疟疾
S Krishna1, A M Taylor, W Supanaranond
1Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Lancet (London, England)
|February 24, 1999
概括
在泰国的疟疾患者中,特别是那些患有严重感染的人中,胺缺乏是常见的. 这种缺陷可以使疟疾病例中中枢神经系统并发症恶化.
科学领域:
- 热带医学 热带医学
- 营养科学 营养科学
- 传染性疾病 传染性疾病
背景情况:
- 胺缺乏症 (beriberi) 在东南亚普遍存在.
- 急性胺缺乏症的症状可能类似于疟疾并发症,如脑病变和乳酸性酸症.
- 这项研究调查了泰国住院疟疾患者的胺缺乏率.
研究的目的:
- 确定在泰国因疟疾住院的成年人中胺缺乏症的发生率.
- 评估与疟疾严重程度相关的胺缺乏症的严重程度.
- 探索胺缺乏对疟疾中枢神经系统功能障碍的潜在贡献.
主要方法:
- 在泰国Paholpolpayuhasena医院进行的前性研究 (1992年5月至7月).
- 招募了连续患有疟疾或发烧疾病的患者和健康的对照.
- 测量了红细胞转基因酶激活系数 (alpha) 来定义胺缺乏 (alpha > 1.31).
主要成果:
- 在52%的严重疟疾患者和19%的无并发性疟疾患者中检测到胺缺乏.
- 与对照组相比,在严重和无并发性疟疾组中,胺缺乏症的发生率明显高.
- 在患有脑疟疾的患者中,缺乏症更为严重.
结论:
- 胺缺乏经常使泰国住院成年人患急性型疟疾复杂化.
- 这种缺陷在患有严重疟疾感染的患者中特别常见和严重.
- 胺缺乏可能导致严重疟疾病例中观察到的中枢神经系统功能障碍.
关键词:
亚洲 亚洲 亚洲 亚洲生物学 生物学 生物学案例和控制研究研究.缺陷疾病 缺陷疾病发展中国家 发展中国家疾病 疾病 疾病疟疾:疟疾是一种疾病.微量营养素 微量营养素 微量营养素营养障碍 营养障碍 营养障碍寄生性疾病 寄生性疾病生理学 生理学 生理学研究方法研究方法研究方法学研究报告 研究报告东南亚的东南亚地区.研究研究研究研究研究研究.泰国 泰国 泰国 泰国维生素 维生素是一种维生素.更多相关视频
04:59Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
Published on: May 30, 2025
07:21Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions
Published on: June 6, 2025
相关概念视频
Menopause
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Depressive Disorders: MDD and Dysthymia
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Fungal Phylum Microsporidia
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
