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更年期的更年期.

G A Greendale1, N P Lee, E R Arriola

  • 1Division of Geriatrics, School of Medicine, Center for Health Sciences, University of California, Los Angeles 90095-1687, USA.

Lancet (London, England)
|February 24, 1999
PubMed
概括
此摘要是机器生成的。

更年期,卵巢功能停止,通常发生在51岁左右. 激素替代疗法为缓解症状和预防慢性病提供了好处,但需要个性化的决策.

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科学领域:

  • 生殖内分泌学 生殖内分泌学
  • 老年学是一门学科.
  • 妇女健康 妇女健康

背景情况:

  • 更年期被定义为由于永久性卵巢功能停止而导致12个月的缺血,平均年龄为51岁.
  • 绝经前期,绝经前的过渡期,涉及改变卵巢功能和症状发作,如热.
  • 更年期过渡的生理学和临床方面尚未完全理解.

研究的目的:

  • 审查有关更年期与各种症状和疾病之间的联系的证据.
  • 讨论用于缓解症状和预防慢性疾病的激素替代疗法 (HRT).
  • 强调基于益处,风险和患者偏好的个性化HRT决策的重要性.

主要方法:

  • 对有关更年期相关症状和疾病的现有证据的审查.
  • 激素替代疗法 (HRT) 指示,疗程和并发症的分析.
  • 检查关于HRT和所有原因死亡率的观察数据.

主要成果:

  • 观察性研究表明,HRT的使用与绝经后妇女全因死亡率减少30-50%有关.
  • HRT可以用于症状管理和预防慢性疾病,剂量和途径各不相同.
  • 在HRT期间意外的阴道出血可能表明子宫内膜增生,需要仔细监测.

结论:

  • 绝经后激素治疗是一种复杂的干预,具有积极和消极的健康影响.
  • 对于HRT来说,个性化决策至关重要,涉及女性和医疗保健提供者之间的联合讨论.
  • 患者对健康结果的偏好应指导选择使用激素替代疗法.