在老年人中增加脉冲压和心力衰竭的风险
C U Chae1, M A Pfeffer, R J Glynn
1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215-1204, USA. chae.claudia@mgh.harvard.edu
JAMA
|February 24, 1999
概括
脉压是衡量动脉硬化的指标,它可以独立预测老年人心脏不全 (CHF) 风险. 较高的脉压显著增加了患心血管衰竭的可能性.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 动脉硬自然会随着年龄的增长而进展.
- 脉压是动脉硬化的关键指标.
- 增加的动脉硬与心血管并发症有关,例如老年人的充血性心力衰竭 (CHF).
研究的目的:
- 为了前性地研究脉冲压与患上充血性心力衰竭 (CHF) 的风险之间的关联.
主要方法:
- 采用了前性队列研究设计.
- 这项研究包括来自东波士顿高级健康项目的1621名老年人 (平均年龄为77.9岁).
- 参与者被跟踪平均3.8年,CHF发病率由医院出院诊断和死亡证明来确定.
主要成果:
- 脉压被确定为心衰竭的独立预测因子,即使经过多种混因素的调整.
- 脉压增加10mm Hg与心脏病风险增加14%相关 (P = .003).
- 脉压最高三分之一 (>67 mm Hg) 的个体,与最低三分之一 (<54 mm Hg) 的个体相比,患心血管衰竭的风险增加了55%.
结论:
- 脉压是老年人群中充血性心力衰竭 (CHF) 风险的重要和独立预测因素.
- 这种易于测量的血液动力学参数为老年人心血管健康提供了宝贵的预后信息.
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