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相关概念视频

Introduction to Functional Groups02:08

Introduction to Functional Groups


Functional groups are group of atoms with specific chemical properties that occur within organic molecules and sometimes denoted as “R”. Functional groups are found along the carbon backbone of macromolecules can form chains or rings of carbon atoms. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of common functional groups
The table below summarizes some of the major functional groups in organic chemistry. (The...
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
π Molecular Orbitals of 1,3-Butadiene01:24

π Molecular Orbitals of 1,3-Butadiene

Conjugated dienes have lower heats of hydrogenation than cumulated and isolated dienes, making them more stable. The enhanced stabilization of conjugated systems can be understood from their π molecular orbitals.
The simplest conjugated diene is 1,3-butadiene: a four-carbon system where each carbon is sp2-hybridized and has an unhybridized p orbital that contains an unpaired electron. According to molecular orbital theory, atomic orbitals combine to form molecular orbitals such that the number...
Electrophilic 1,2- and 1,4-Addition of HX to 1,3-Butadiene01:17

Electrophilic 1,2- and 1,4-Addition of HX to 1,3-Butadiene

The electrophilic addition of hydrogen halides such as HBr to alkenes and nonconjugated dienes gives a single product as per Markovnikov’s rule.
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
Overview of Functional Groups01:19

Overview of Functional Groups

Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, certain functional groups will make a molecule hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each functional group is a unique...

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相关实验视频

Updated: Jul 11, 2026

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis
11:29

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis

Published on: December 18, 2014

作为索或三烯结合模块的WW域的功能

P J Lu1, X Z Zhou, M Shen

  • 1Cancer Biology Program, Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

Science (New York, N.Y.)
|February 26, 1999
PubMed
概括
此摘要是机器生成的。

研究人员发现,WW域,特别是Pin1WW域,充当索氨酸或索氨酸结合模块. 这种结合对蛋白质相互作用和Pin1的相互作用至关重要.

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Synthesis and Characterization of Functionalized Metal-organic Frameworks
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On-line Analysis of Nitrogen Containing Compounds in Complex Hydrocarbon Matrixes

Published on: August 5, 2016

相关实验视频

Last Updated: Jul 11, 2026

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis
11:29

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis

Published on: December 18, 2014

Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

On-line Analysis of Nitrogen Containing Compounds in Complex Hydrocarbon Matrixes
07:49

On-line Analysis of Nitrogen Containing Compounds in Complex Hydrocarbon Matrixes

Published on: August 5, 2016

科学领域:

  • 分子生物学分子生物学
  • 细胞信号传递 细胞信号传递
  • 蛋白质生物化学 蛋白质生物化学

背景情况:

  • 蛋白相互作用模块决定了信号传导的特异性.
  • 酸化调节信号复合体的组合.
  • 已知氨酸结合模块,但氨酸/氨酸结合模块尚未描述.

研究的目的:

  • 描述WW域的绑定属性.
  • 研究WW域在蛋白质-蛋白质相互作用和信号传递中的作用.
  • 为了确定WW域是否可以结合索或三烯残留物.

主要方法:

  • 研究了来自Pin1和Nedd4.4的WW域.
  • 评估了以酸化依赖的方式与脂蛋白结合.
  • 在体外和体内研究了索/三氨酸结合对Pin1活性的功能要求.

主要成果:

  • 1和Nedd4的WW域与蛋白结合,包括酶基质.
  • 在Pin1 WW域的功能作为索/三胺结合模块.
  • 这种结合活性对于Pin1的基质相互作用和体内功能至关重要.

结论:

  • WW域代表了一种新型的索/氨酸结合模块类.
  • 通过特定的蛋白识别,Pin1的WW域对其生物作用至关重要.
  • 这一发现扩大了对通过酸化依赖相互作用的信号复杂调节的理解.