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在尿病原体中,抗菌素耐药性的患病率越来越高,导致女性急性无并发性囊炎
K Gupta1, D Scholes, W E Stamm
1Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA.
JAMA
|March 3, 1999
概括
对常见囊炎治疗方法的抗微生物耐药性,如三甲胺-硫甲醇,在女性中显著增加. 然而,耐黄和西普罗夫洛克萨的耐药性仍然很低,提供了替代的经验性治疗选择.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 对急性无并发性囊炎的实证治疗依赖于可预测的尿病原体抗性模式.
- 了解抗微生物敏感性对于有效的治疗指南至关重要.
研究的目的:
- 确定导致女性急性无并发性囊炎的尿病原体中抗菌素耐药性的流行率和趋势.
- 根据当前的耐药性数据,为实证治疗策略提供信息.
主要方法:
- 一个5年的横截面调查 (1992-1996) 从18-50岁的妇女与急性囊炎的尿液分离.
- 对常见泌尿病原体,主要是大肠杆菌和葡萄球菌saprophyticus的抗微生物敏感性模式的分析.
主要成果:
- 大肠杆菌和葡萄球菌 (Staphylococcus saprophyticus) 占 90% 的分离物.
- 每年观察到超过20%的抗安培素,甲和硫甲醇的耐药性.
- 大肠杆菌对三甲-硫甲醇的耐药性从超过9% (1992年) 增加到超过18% (1996年).
- 尼托福兰,珍塔米辛和西普罗夫洛克萨具有较低的耐药性 (<10%) 和稳定的敏感性模式.
结论:
- 观察到对三甲胺-硫甲醇,安西林和脑素的耐药性显著增加.
- 尼托福兰和西普罗夫洛克萨显示持续的低耐药性,仍然是有效的选择.
- 敏感性数据,以及疗效和成本,应指导急性无并发性囊炎的经验性治疗选择.
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