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相关概念视频

LTR Retrotransposons03:08

LTR Retrotransposons

LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Convolution Properties I01:20

Convolution Properties I

Convolution computations can be simplified by utilizing their inherent properties.
The commutative property reveals that the input and the impulse response of an LTI (Linear Time-Invariant) system can be interchanged without affecting the output:
Inverse z-Transform by Partial Fraction Expansion01:20

Inverse z-Transform by Partial Fraction Expansion

The inverse z-transform is a crucial technique for converting a function from its z-domain representation back to the time domain. One effective method for finding the inverse z-transform is the Partial Fraction Method, which involves decomposing a function into simpler fractions with distinct coefficients. These fractions correspond to known z-transform pairs, facilitating the inverse transformation process.
To begin the process, the poles of the function are identified and the function is...
First Order Systems01:21

First Order Systems

First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
Phase-lead and Phase-lag Controllers01:22

Phase-lead and Phase-lag Controllers

Understanding the working function of different types of controllers can be illustrated with practical analogies, such as adjusting a stereo's volume equalizer. Cranking up the bass involves a phase-lead controller, which functions as a high-pass filter, while increasing the treble uses a phase-lag controller, which acts as a low-pass filter. PD controllers, similar to high-pass filters, enhance the system's response to high-frequency components. PI controllers, akin to low-pass filters, manage...

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相关实验视频

Updated: Jul 13, 2026

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies
08:21

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Published on: March 20, 2015

通过L1反向转换进行前子混合.

J V Moran1, R J DeBerardinis, H H Kazazian

  • 1Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104-6145 USA. moranj@umich.edu

Science (New York, N.Y.)
|March 5, 1999
PubMed
概括

长间隔的核元素 (LINE-1s) 将非LINE-1序列,如前子,调动到新的基因组位置. 这种逆转换机制可能推动新基因的进化.

科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 进化生物学 进化生物学

背景情况:

  • 长间隔的核元素 (LINE-1s或L1s) 是人类基因组中丰富的逆转移体.
  • L1s是逆转录酶活性的主要来源,对于它们自身的复制和动员至关重要.

研究的目的:

  • 研究工程逆转换能力强的L1元素的插入偏好和动员能力.
  • 为了确定L1s是否可以调动相邻的非L1基因组序列.

主要方法:

  • 在培养的人类细胞中利用工程制造的长间隔核元素 (L1s).
  • 使用分子技术分析L1插入和逆转移序列的基因组位置.

主要成果:

  • 工程L1s在培养的人类细胞中展示了高频逆转换.
  • 在转录的基因内观察到L1插入.
  • 从L1元素的3'侧面的序列被反转移到新的基因组位置.

结论:

  • 具有逆转换能力的L1s可以调动非L1序列,包括外子和促进子.
  • 这种动员机制可以通过将现有序列整合到新文本中来促进新基因的进化.

更多相关视频

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
11:52

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level

Published on: April 23, 2016

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR
10:54

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

Published on: July 27, 2019

相关实验视频

Last Updated: Jul 13, 2026

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies
08:21

Laser-induced Forward Transfer for Flip-chip Packaging of Single Dies

Published on: March 20, 2015

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
11:52

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level

Published on: April 23, 2016

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR
10:54

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

Published on: July 27, 2019