相关实验视频
Updated: Jul 13, 2026
11:10
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
在缺乏蛋白质氨酸酸酶-1B基因的小鼠中增加胰岛素敏感性和抗肥胖性
M Elchebly1, P Payette, E Michaliszyn
1Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6.
Science (New York, N.Y.)
|March 5, 1999
概括
移除蛋白氨酸酸酶-1B (PTP-1B) 改善了小鼠的胰岛素敏感性和葡萄糖代谢. 缺乏PTP-1B也可以防止饮食引起的肥胖和胰岛素抵抗.
科学领域:
- 生物化学 生物化学
- 代谢研究研究 代谢研究
背景情况:
- 蛋白氨酸酸酶-1B (PTP-1B) 对胰岛素信号进行负面调节.
- 研究PTP-1B的作用对于了解代谢障碍至关重要.
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Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...