年轻和中年妇女流感相关的发病率和死亡率
K M Neuzil1, G W Reed, E F Mitchel
1Department of Medicine, University of Washington School of Medicine, and the Veterans Affairs Medical Center, Seattle, USA.
JAMA
|March 17, 1999
概括
患有慢性疾病的65岁以下妇女面临严重的流感风险. 针对这些高风险妇女的年度流感免疫接种对于减少住院和死亡至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 关于65岁以下成年人流感相关住院和死亡的数据有限.
- 了解这些风险对于有针对性的公共卫生干预至关重要.
研究的目的:
- 量化65岁以下妇女因流感的严重发病率和死亡率.
- 评估包括艾滋病毒在内的慢性疾病对流感相关结果的影响.
主要方法:
- 在田纳西州医疗补助计划 (1974-1993) 中报名的15-64岁妇女的回顾性队列研究.
- 分析了在流感季节与近流感季节期间因急性心肺疾病住院和死亡的情况.
- 通过比较季节之间的事件率来计算流感可归因的风险.
主要成果:
- 在流感季节,急性心肺事件的发生率始终较高.
- 在高风险妇女中,每年发生的多余事件为每10,000人中23-58人 (住院/死亡),每10,000人中2人 (死亡).
- 没有高风险疾病的女性的过量事件较少 (10,000人中4-6人).
结论:
- 患有慢性疾病的65岁以下妇女经历了大量的流感发病率和死亡率.
- 加强针对这些高风险人群的流感免疫战略是有必要的.
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