红杉蛋白是一种参与抑制肥胖的受体
D L Nagle1, S H McGrail, J Vitale
1Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.
Nature
|March 23, 1999
概括
研究人员确定了红杉基因,在小鼠中抑制肥胖. 这一发现对于理解饮食引起的肥胖和潜在的人类治疗干预措施至关重要.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 神经科学是一个神经科学.
背景情况:
- 红杉基位的突变抑制了agouti-致命黄色小鼠的肥胖.
- 红杉基因的产物和功能以前是未知的.
研究的目的:
- 为了识别红杉基因及其蛋白质产物.
- 调查红木在调节体重和养中的作用.
- 探索红杉作为治疗肥胖的治疗目标的潜力.
主要方法:
- 在小鼠中对红杉基因的定位克隆.
- 在现场杂交以确定基因表达模式.
- 基因研究评估各种肥胖模型的抑制.
主要成果:
- 鉴定了红杉基因,证实了其广泛表达,特别是在中腹下丘脑核中.
- 红杉在黑色皮质素-4受体无或其他单一性肥胖模型中不会抑制肥胖.
- 红杉可以有效地抑制饮食引起的肥胖.
结论:
- 红杉基因产物是一种大型的跨膜受体样分子.
- 红杉的抑制饮食引起的肥胖机制可能为人类肥胖疗法提供了洞察力.
- 需要进一步的研究来阐明红杉的精确信号通路.
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