在怀孕期间感染帕尔沃病毒B19的危险因素
A K Valeur-Jensen1, C B Pedersen, T Westergaard
1Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen.
JAMA
|April 3, 1999
概括
孕妇在流行病期间面临帕尔沃病毒B19感染的高风险,特别是与儿童接触的增加. 大多数感染源于与女性自己的孩子接触,这突出了严重的公共卫生问题.
科学领域:
- 流行病学 流行病学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 怀孕期间的帕尔沃病毒B19感染与胎儿死亡有关.
- 关于孕妇感染发病率和风险因素的数据有限.
研究的目的:
- 为了确定在流行病和流行病期间孕妇感染帕尔沃病毒B19的风险.
- 在这个人群中识别与帕尔沃病毒B19感染相关的风险因素.
主要方法:
- 一项基于人口的队列研究,涉及丹麦 (1992-1994) 的30946名孕妇.
- 血清样本评估特定的IgG抗体,以确定过去的感染和血清转化.
- 收集了关于家庭结构,教育,社会经济地位和怀孕结果的数据.
主要成果:
- 65%的孕妇有证据表明过去曾感染过帕尔沃病毒B19.
- 年度血清转化率为1.5% (流行病) 和13.0% (流行病).
- 风险因素包括兄弟姐妹的数量,同龄兄弟姐妹,自己的孩子和职业接触儿童. 幼儿园教师的风险增加了3倍.
结论:
- 易受感染的孕妇在流行病期间面临感染的高风险,与儿童接触水平相关.
- 虽然幼儿园教师的职业风险较高,但大多数感染源于与妇女自己的孩子接触.
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