在孕期暴露于有机溶剂后的怀孕结果:一项前性受控研究
S Khattak1, G K-Moghtader, K McMartin
1The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, and the University of Toronto, Ontario, Canada.
JAMA
|April 3, 1999
概括
在怀孕期间对有机溶剂的职业暴露显著增加了胎儿重大发育不全的风险. 遇到与溶剂暴露相关的症状的女性面临更高的风险,这强调了尽量减少暴露的必要性.
科学领域:
- 职业健康 职业健康 职业健康
- 生殖毒理学 生殖毒理学
- 甲状腺学 甲状腺学
背景情况:
- 许多处于生育年龄的妇女面临着职业暴露在有机溶剂中.
- 之前关于有机溶剂致病风险的研究已经产生了相互矛盾的结果.
研究的目的:
- 调查职业接触有机溶剂的妇女的怀孕和胎儿后果.
- 评估与母亲职业溶剂暴露相关的产性风险.
主要方法:
- 进行了一项前性,观察性,受控研究.
- 125名怀孕妇女在怀孕早期就业接触有机溶剂,与接触非致病原体的对照进行了匹配.
- 主要的先天性形是主要的结局指标.
主要成果:
- 与对照组相比,暴露于有机溶剂的女性胎儿的重大发育不全发生率显著更高 (RR, 13.0).
- 在暴露的女性中,在那些与暴露暂时相关的症状的女性中,发生了12种发育不良,而在无症状女性中没有 (P<.001).
- 与对照组相比,暴露的妇女报告了较高的先前流产率 (46.2%与19.2%相比;P<.001).
结论:
- 怀孕期间对有机溶剂的职业暴露与重大胎儿形的风险增加有关.
- 对有机溶剂的症状暴露似乎预测了胎儿更高的发育不良风险.
- 建议尽量减少孕妇对有机溶剂的职业暴露.
相关概念视频
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...