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相关概念视频

Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

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相关实验视频

Updated: Jul 10, 2026

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
08:28

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

儿童血清homocysteine水平的分布和相关因素:心血管健康儿童和青少年试验.

S K Osganian1, M J Stampfer, D Spiegelman

  • 1New England Research Institutes, Watertown, Mass 02472, USA. voulao@neri.org

JAMA
|April 13, 1999
PubMed
概括

儿童的血清homocysteine水平低于成年人,但有些儿童可能面临心血管疾病的风险. 叶酸水平在年轻人中显著影响同型半氨酸度.

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The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
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Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
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Last Updated: Jul 10, 2026

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
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科学领域:

  • 儿科心血管健康和代谢风险因素.
  • 营养生物化学及其对青少年健康的影响.

背景情况:

  • 同类氨酸是已知的心血管疾病风险因素在成年人.
  • 关于儿童的同类氨酸水平及其决定因素的数据有限.

研究的目的:

  • 为了确定血清同型半氨酸度在儿童中的分布.
  • 调查同类氨酸水平与叶酸,维生素B12和维生素B6等因素之间的关联.

主要方法:

  • 对3524名13-14岁的美国学生进行了横截面分析.
  • 测量非禁食的血清总同类半氨酸,叶酸,维生素B12和维生素B6.
  • 从一项基于学校的队列研究 (心血管健康儿童和青少年试验) 中收集的数据.

主要成果:

  • 血清中的同类半氨酸水平在0.1至25.7微摩尔/升之间 (中位数为4.9).
  • 在男孩,黑人儿童,非复合维生素使用者和吸烟者中观察到更高的homocysteine度.
  • 同类氨酸与血清叶酸,维生素B12和维生素B6具有显著的反相关性.

结论:

  • 儿童的同类半氨酸水平低于成人水平,但儿童的一个子集可能有较高的风险.
  • 血清叶酸似乎是儿童同型半氨酸水平的关键决定因素.
  • 同型半氨酸水平独立地与性别,种族,血清叶酸/B12以及经调整后的缩血压有关.