前庭 natriuretic对肌肉交感活动及其反射控制在人类心力衰竭的作用
B L Abramson1, S Ando, C F Notarius
1Divisions of Cardiology, the Toronto Hospital and Mount Sinai Hospital, and the Centre for Cardiovascular Research, University of Toronto.
Circulation
|April 13, 1999
概括
耳前 natriuretic (ANP) 抑制肌肉交感神经活动 (MSNA) 在心力衰竭患者,即使在下体负压 (LBNP). 当心房压力下降而不影响全身血压时,这种同情抑制作用是显而易见的.
科学领域:
- 心血管生理学心血管生理学
- 神经内分泌学神经内分泌学
- 心脏衰竭病理生理学 病理生理学
背景情况:
- 心力衰竭与交感神经系统活动的改变有关.
- 耳前 natriuretic (ANP) 是一种具有已知的血管扩张和 natriuretic 作用的激素.
- 在心力衰竭中,ANP对交感神经活动的影响尚未完全理解.
研究的目的:
- 为了研究心力衰竭患者ANP的交感抑制作用.
- 确定ANP是否调节静止状态下和下体负压 (LBNP) 期间的肌肉交感神经活动 (MSNA).
主要方法:
- 十五名患有扩张性心肌病的男性作为对照对ANP和酸甘油 (NTG) 进行了静脉注射.
- 血液动力学参数包括血压 (BP),中央静脉压 (CVP) 和心率 (HR) 被监测.
- 肌肉交感神经活动 (MSNA) 在休息状态和LBNP (-6和-12 mm Hg) 期间被记录.
主要成果:
- 无论ANP和NTG都类似地降低了心血管压力和腹筋压力.
- 休息的MSNA在两种输液中都没有增加.
- LBNP诱导CVP和BP的减少,在ANP和NTG期间具有类似的效果.
- 在安普输注期间,MSNA显著降低,无论是在休息状态还是在LBNP期间.
- 在NTG期间非潜在的LBNP增加了MSNA,但在ANP期间没有.
结论:
- 在心力衰竭患者中,ANP具有同情抑制作用.
- 当ANP降低心房压力而不会改变全身血压时,这种效应最明显.
- 在心力衰竭中,ANP可能在调节交感过度活性的过程中发挥作用.
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