在跑步机测试期间血压反应作为新发高血压的风险因素. 弗雷明翰心脏研究
J P Singh1, M G Larson, T A Manolio
1National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Circulation
|April 13, 1999
概括
在运动期间过度扩散性血压 (DBP) 反应预测男性和女性的新发高血压. 恢复性静脉压升高 (SBP) 也表明男性的高血压风险,表明临床前高血压变化.
科学领域:
- 心血管医学 心血管医学
- 高血压研究 高血压研究
- 运动生理学 运动生理学
背景情况:
- 之前关于运动血压反应和高血压预测的研究仅限于小型男性队列.
- 运动和康复血压与未来高血压风险之间的关联在一个大规模的,基于人口的男性和女性样本中未被检查.
研究的目的:
- 调查运动和康复期间缩血压 (SBP) 和腹缩血压 (DBP) 与新发高血压的发生率之间的关系.
- 评估这些关联在一个大规模的,以人口为基础的样本中,对正常压力中年男性和女性进行评估.
主要方法:
- 利用来自Framingham后代研究的1026名男性和1284名女性的数据,这些人在基线时是正常的.
- 在分级跑步机炼和恢复期间评估血压 (BP),定义过度反应和延迟恢复.
- 随访参与者8年,以确定新发高血压的发生率 (SBP≥140 mm Hg,DBP≥90 mm Hg,或开始服用抗高血压药物).
主要成果:
- 在8年内,新发高血压发生在22%的男性和16%的女性中.
- 在运动期间过度的DBP反应 (Ex-DBP 2) 强烈预测男性 (OR, 4.16) 和女性 (OR, 2.17) 的事件高血压.
- 延迟SBP恢复 (R-SBP 3) 预测了男性的高血压 (OR, 1.92),特别是在考虑运动持续时间和峰值运动BP时.
结论:
- 在运动期间过度扩张的舒张血压反应是两性未来高血压的重要预测因素.
- 运动后恢复期间心血压升高与男性高血压风险增加有关.
- 这些运动引起的血压变化可能表明高血压临床前阶段的亚临床病理生理学变化.
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