布托芬醇酸对内心心动脉逆转动期间与冲击相关的不适的影响
C Timmermans1, L M Rodriguez, G M Ayers
1Department of Cardiology, Academic Hospital Maastricht, The Netherlands. C.Timmermans@cardio.azm.nl
Circulation
|April 13, 1999
概括
鼻内注射的布托尔法 (一种阿片类药物) 有效地减少了心房除期间的疼痛. 这种止痛药提高了患者的舒适度,而不增加恐惧,使手术更容易接受.
科学领域:
- 心脏病学 心脏病学
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对心房动的心脏内心动脉阻可以引起患者显著的不适.
- 需要一种快速起作用的止痛药和抗焦虑药来改善患者对该程序的耐受性.
研究的目的:
- 评估鼻腔内布托尔法作为内心心动脉逆转动期间止痛和抗焦虑药的疗效.
- 评估Butorphanol对疼痛和恐惧感知的影响在升级式除协议期间.
主要方法:
- 这是一项双盲,安慰剂控制的研究,涉及47名接受内心动脉缩的患者.
- 患者接受了鼻入布托尔法诺或安慰剂,根据需要给予额外剂量.
- 在每次冲击后,使用麦吉尔疼痛问卷 (PRI) 和视觉模拟量表 (VAS) 评估疼痛和恐惧.
主要成果:
- 在除方案的第二阶段,鼻内布托尔法显著降低了疼痛评级指数 (PRI) 总,感觉和评估得分.
- 与安慰剂相比,接受布托尔法诺的患者在过渡到II阶段时显示疼痛得分明显较低 (VAS-P,PRI-T,PRI-S,PRI-E).
- 在手术过程中,丁醇没有显著影响恐惧 (VAS-F) 水平.
结论:
- 鼻内注射的布托尔法能有效地减轻与内心动脉逆转动相关的疼痛.
- 止痛效应主要针对感觉和评价性疼痛组件,不影响情感组件.
- 这项研究表明,鼻入布托尔法是改善心房除期间患者舒适度的可行选择,而PRI是比VAS更准确的疼痛评估工具.
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