ApoCIII基因变异调节了对葡萄糖和脂肪耐受性测试的食后反应
D M Waterworth1, J Ribalta, V Nicaud
1Division of Cardiovascular Genetics, Department of Medicine, The Rayne Institute, University College London, UK. rmhadw@ucl.ac.uk
Circulation
|April 13, 1999
概括
在阿波利波蛋白CIII基因中的遗传变异会影响身体在饭后如何处理脂肪和糖. 特定变异会影响甘油三清除和葡萄糖/胰岛素反应,可能会影响动脉样硬化风险.
科学领域:
- 遗传学 遗传学 是一个
- 代谢健康 代谢健康
- 心血管疾病的风险风险
背景情况:
- 研究的阿波利波蛋白 (apo) AI-CIII-AIV基因集群变异与代谢反应相关.
- 研究了父亲早发心肌梗塞 (MI) 的年轻男性后代.
- 比较病例 (n=407) 与年龄匹配的对照 (n=415).
研究的目的:
- 确定apocIII基因变异与对口服葡萄糖 (OGTT) 和脂肪负载 (OFTT) 的代谢反应之间的关系.
- 探索将这些遗传变异与动脉样硬化风险联系在一起的潜在机制.
主要方法:
- 检查了特定的apoCIII基因变异:C3238G (SstI),C1100T,C-482T (IRE) 和T-2854G. 这些变异包括:
- 使用口服的葡萄糖耐受性测试 (OGTT) 和口服脂肪负荷测试 (OFTT).
- 分析了饭后的甘油三,葡萄糖和胰岛素度.
主要成果:
- 在OFTT之后,T-2854G和C3238G变异影响了食后甘油三清除率 (Tg).
- G-2854等位基因携带者显示Tg清除显著延迟.
- C-482T变异影响了OGTT反应,T-482载体呈现高葡萄糖和胰岛素水平.
结论:
- 特定的apoCIII基因变异对食后代谢反应有不同的影响.
- 在apoCIII位点的遗传变异可能代表一种影响动脉样硬化风险的新机制.
- 研究结果强调了遗传因素在新陈代谢调节和心血管健康中的作用.
相关概念视频
Cell Specific Gene Expression
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Hormones Regulating Blood Glucose
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
Overview of Carbohydrate Metabolism
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Glucose Homeostasis: Regulation of Blood Glucose
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...


