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β-catenin调节结肠癌细胞中cyclin D1的表达

O Tetsu1, F McCormick

  • 1University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143-0128, USA.

Nature
|April 14, 1999
PubMed
概括

大肠腺多瘤 (APC) 基因的突变导致β-catenin的积累,导致结肠癌. 这种β-catenin激活环素D1,促进细胞循环的进展和瘤的生长.

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