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相关概念视频

Arteries and Arterioles01:16

Arteries and Arterioles

Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles and...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

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相关实验视频

Updated: Jun 30, 2026

The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
08:53

The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

在体外培养的功能性动脉.

L E Niklason1, J Gao, W M Abbott

  • 1Department of Anesthesia, Duke University, Durham, NC 27710, USA. nikla001@mc.duke.edu

Science (New York, N.Y.)
|April 16, 1999
PubMed
概括

研究人员使用光滑肌肉和内皮细胞设计了血管移植. 这些组织工程血管移植显示出高强度和收缩功能,显示出未来临床应用的潜力.

科学领域:

  • 生物医学工程 生物医学工程
  • 再生医学是一种再生医学.
  • 血管生物学 血管生物学

背景情况:

  • 血管移植的发展对于治疗心血管疾病至关重要.
  • 目前的移植面临诸如血栓形成和感染等局限性.
  • 组织工程为创造功能性血管替代物提供了一个有希望的替代方案.

研究的目的:

  • 开发一种组织工程策略,用于生产血管移植材料.
  • 描述工程血管移植的机械和生物特性.
  • 为了评估组织工程动脉的体内性能.

主要方法:

  • 从牛血管组织活检中分离出血管细胞 (光滑肌肉和内皮细胞).
  • 细胞被培养并播种在脚手架上,以创建血管移植.
  • 植入物在脉动条件下培养,以模仿生理流动.
  • 评估了机械性能 (破裂强度,留) 和细胞分化标记物.
  • 在微型猪体内进行了体内植入,通过数字血管学监测透视度.

主要成果:

  • 经过工程设计的牛体容器表现出高破裂强度 (>2000 mmHg) 和接保持强度 (高达90 g).
  • 培养的血管表现出对药理剂的收缩反应.

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相关实验视频

Last Updated: Jun 30, 2026

The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
08:53

The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

In Vitro Model of Coronary Angiogenesis
08:03

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

In Vitro 3D Cell-Cultured Arterial Models for Studying Vascular Drug Targeting Under Flow
07:00

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Published on: March 14, 2021

  • 移植体内的光滑肌细胞显示了分化标记 (calponin,肌重链).
  • 植入的组织工程动脉在小型猪中保持了长达24天的专利.

    • 结论:

    • 建立了一个可行的组织工程方法来创建功能性血管移植.
    • 工程血管移植具有有前途的机械和生物特性.
    • 在体内穿透性表明血管重建中的临床翻译潜力.