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Updated: Aug 16, 2026

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在 presenilin-1 中需要两种跨膜亚斯巴酸盐,用于 presenilin 内蛋白解和玛分泌酶活性

M S Wolfe1, W Xia, B L Ostaszewski

  • 1Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. mwolfe@utmem.edu

Nature
|April 17, 1999
PubMed
概括

presenilin-1 中的两个酸残留物对马分泌酶活性至关重要,这与阿尔茨海默病的发病有关. 影响这些阿斯巴酸盐的突变减少了粉样蛋白β的产生,为疾病机制提供了洞察力.

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