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Mass Histology to Quantify Neurodegeneration in Drosophila
Published on: December 15, 2016
神经性表现型和改变的Drosophila Presenilin突变体中的Notch处理
Y Ye1, N Lukinova, M E Fortini
1Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Nature
|April 17, 1999
概括
普雷西尼林对于Notch信号传递至关重要,影响胚胎发育和潜在的阿尔茨海默病病原体. 失去了前林功能会破坏诺奇受体的处理和信号传递,影响细胞发育.
科学领域:
- 发育生物学 发展生物学
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 普列尼林蛋白涉及到诺奇信号传递和阿尔茨海默病.
- 普雷西尼林功能障碍导致发育缺陷,并且与阿尔茨海默病中的粉样蛋白前体蛋白 (APP) 处理有关.
研究的目的:
- 为了研究 presenilin 在 Notch 信号中的作用,使用 Drosophila.
- 阐明 presenilin 影响诺奇受体成熟和信号传递的机制.
主要方法:
- 在Drosophila Presenilin基因中产生功能丧失突变.
- 分析了由此产生的胚胎和发育表型.
- 评估了对Notch受体处理和信号通路的影响.
主要成果:
- 普雷西尼林突变导致致命的诺奇类表型,包括发育缺陷和横向抑制的丧失.
- 普列尼林对于碳氧终端诺奇碎片的蛋白质分解产生至关重要.
- 普雷西尼林在Notch.的膜结合和激活核形式上游起作用.
结论:
- 普雷西尼林在诺奇受体的成熟和信号传递中起着至关重要的作用.
- 研究结果表明,Notch.有不同的细胞外处理点或修改.
- 这项研究将 presenilin 在 Notch 信号中的作用与其参与与阿尔茨海默病相关的粉样蛋白产生联系起来.
相关概念视频
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...