预测人口中的突然死亡:巴黎前性研究I
1Service de Cardiologie, Hôpital Boucicaut, Paris, France. xavier.jouven@bcc.ap-hop-paris.fr
Circulation
|April 20, 1999
概括
父母突然死亡病史是中年男性突然死亡的独立风险因素. 这一发现有助于识别患有早期预防策略风险较高的个体.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 流行病学 流行病学
背景情况:
- 突然死亡与冠状动脉事件具有共同的风险因素,使得具体的预测变得困难.
- 父母突然死亡的病史以前没有被调查为风险因素.
研究的目的:
- 在长期队列研究中评估突然死亡的风险因素,包括父母的突然死亡.
主要方法:
- 从巴黎前性研究I (1967-1972) 中对7746名男性 (43-52岁) 的分析.
- 通过体检,心电图,实验室测试和详细的家庭病史问卷收集的数据.
- 排除已知缺血性心脏病的男性;生命状况平均追踪23年.
主要成果:
- 确定了突发死亡的独立风险因素:静止心率,血压,吸烟,BMI,糖尿病,胆固醇和父母的突发死亡史.
- 父母突然死亡与1.80倍增加的突然死亡相对风险 (95% CI,1.11-2.88),独立于其他混因素.
结论:
- 父母突然死亡是中年男性突然死亡的独立风险因素.
- 突发死亡的家族风险因素可以改善高风险个体的识别,并促进早期预防.
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