怀孕期间梅本达治疗对出生结果的影响
N R de Silva1, J L Sirisena, D P Gunasekera
1Faculty of Medicine, University of Kelaniya, Sri Lanka. nrdes@mail.lanka.net
Lancet (London, England)
|April 21, 1999
概括
梅本达对于在流行地区的孕妇来说是安全的,减少了不良分娩结果. 然而,避免在第一季度使用,以防止潜在的先天性缺陷.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 虫感染在发展中国家普遍存在,导致孕妇贫血.
- 产前梅本达可以减少贫血,但其在怀孕期间的安全性尚未确立.
- 评估梅本达对出生结果的影响对于其更广泛的采用至关重要.
研究的目的:
- 评估怀孕期间梅本达治疗的安全性和有效性.
- 确定梅本达使用与出生结果之间的关联,包括先天性缺陷,死胎,围产死亡和低出生体重.
主要方法:
- 在斯里兰卡进行了一项横截面研究.
- 在怀孕期间服用梅本达的母亲与对照组的分娩结果进行比较.
- 分析了主要先天性缺陷,死胎,围产期死亡和低出生体重 (<2500g) 的比例.
主要成果:
- 与对照组相比,在梅本达组中没有观察到重大先天性缺陷的显著增加.
- 在怀孕的第一季度使用梅本达显示出先天性缺陷的非显著增加.
- 在mebendazole组中发现死亡出生率,围产期死亡率和低出生体重率明显较低.
结论:
- 怀孕期间的梅本达治疗与重大先天性缺陷的显著增加无关.
- 在怀孕的第一季度应避免使用梅本达.
- 产前梅本达可能为肠道虫病特有地区的孕妇提供好处.
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