静脉血栓症:一种多原因的疾病
1Department of Clinical Epidemiology and the Hemostasis and Thrombosis Research Center, Leiden University Medical Center, The Netherlands.
Lancet (London, England)
|April 21, 1999
概括
静脉血栓形成的危险因素与动脉疾病有所不同. 最近的发现强调了凝血异常和基因相互作用是理解血栓形成的关键.
科学领域:
- 心血管医学 心血管医学
- 遗传学 是一个遗传学.
- 血液学 血液学 血液学
背景情况:
- 静脉血栓症和动脉血管疾病共享一些危险因素,但具有不同的病因路径.
- 在了解静脉血栓形成病因方面,在过去五年中取得了进展.
- 凝血异常被认为是导致血栓形成的重要因素.
研究的目的:
- 探索对静脉血栓瘤风险因素的不断变化的理解.
- 为了强调凝血异常在血栓形成中的作用.
- 研究遗传和环境因素在血栓形成中的相互作用.
主要方法:
- 关于静脉血栓症的最新科学文献的审查.
- 对遗传和环境风险因素的分析.
- 探索基因与基因和基因与环境的相互作用.
主要成果:
- 凝血异常在一般人群中很普遍.
- 在个体中,多种风险因素可以并存.
- 基因-基因和基因-环境相互作用对于解释血栓发生至关重要.
结论:
- 了解多种风险因素之间的复杂相互作用对于预测个人血栓形成风险至关重要.
- 对遗传倾向和环境触发因素的进一步研究是有必要的.
- 静脉血栓的病因是多因素的,涉及遗传和获得因素的组合.
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