无脂蛋白E多态与头部损伤后的结果的关联
G M Teasdale1, J A Nicoll, G Murray
1University Department of Neurosurgery, University of Glasgow, UK. y.galbraith@clinmed.gla.ac.uk
Lancet (London, England)
|April 23, 1999
概括
阿波利波蛋白E (APOE) epsilon4基因基因与头部受伤后更糟糕的结果有关. 患有APOE epsilon4的患者在受伤6个月后恢复不良的可能性是超过两倍.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 创伤学 创伤学 创伤学
背景情况:
- 对头部损伤结果的预后因素是不完整的.
- 阿波蛋白E (APOE) 基因多态性影响致命头部伤害的神经病理学.
- APOE epsilon4基因与大脑皮层中的粉样β蛋白沉积物有关.
研究的目的:
- 为了测试APOE epsilon4基因基因携带者是否经历了头部损伤后6个月的更糟糕的临床结果,与非携带者相比.
- 研究APOE多态性对创伤性脑损伤预后的遗传影响.
主要方法:
- 对93名患者进行前性研究,这些患者在头部受伤后入住了神经外科病房.
- 使用格拉斯哥昏迷评分 (GCS) 评估初始损伤严重程度.
- 使用格拉斯哥结论量表评估六个月的结果;通过标准血液样本分析进行APOE基因定型.
主要成果:
- 在30名 (57%) APOE epsilon4患者中,有17名有不良结果,而59名 (27%) 非载体患者中,有16名有不良结果 (p=0.006).
- 在对年龄,GCS和CT扫描结果进行控制后,这种显著的关联仍然存在 (p=0.024).
结论:
- 在APOE多态和头部损伤结果之间发现了显著的遗传关联.
- 携带APOE epsilon4的携带者在头部受伤6个月后,不良结果的可能性是2倍以上.
- 进一步的研究正在进行中,以验证和探索这种遗传联系.
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