在老鼠的鼻系统中,感觉神经元的轴突投射的可变模式
I Rodriguez1, P Feinstein, P Mombaerts
1Rockefeller University, New York, New York 10021, USA.
Cell
|April 29, 1999
概括
缺少VR2费洛蒙受体基因的小鼠显示出鼻系统的线路受损. 然而,另一种气味受体M71可以部分补偿VR2的功能.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 哺乳动物的感官系统
背景情况:
- 吐口鼻系统对于哺乳动物的费罗蒙通信至关重要.
- 了解这个系统的遗传基础和神经元连接是解读社会行为的关键.
研究的目的:
- 为了研究假设的费洛蒙受体基因VR2在鼻系统中的作用.
- 描述VR2表达神经元的表达模式和轴突投射.
- 为了确定VR2基因破坏的功能后果.
主要方法:
- 用基因向技术在小鼠中创建VR2基因突变.
- 组织学标记物 (taulacZ和tauGFP) 用于跟踪神经元表达和投射.
- 进行了VR2编码区域的删除和对一个无关的气味受体 (M71) 影响的分析.
主要成果:
- 在单个吐口鼻神经元中,VR2以单个基形式表达.
- 来自VR2表达神经元的轴突投射到附属嗅球中的特定球粒,具有复杂和可变的图案.
- 破坏VR2基因改变了这个投影模式.
- 气味受体M71证明了对VR2的部分补偿作用.
结论:
- VR2在鼻系统的正确布线中发挥着重要作用.
- 与主要的嗅觉系统相比,口腔鼻腔系统表现出明显的布线逻辑.
- 在费洛蒙受体系统中存在功能冗余或替代,正如M71对VR2功能的部分救援所表明的那样.
相关概念视频
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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
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