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在使用SHIVs感染CCR5或CXCR4的 rhesus中明显的病原性序列

J M Harouse1, A Gettie, R C Tan

  • 1Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA.

Science (New York, N.Y.)
|April 30, 1999
PubMed
概括

猿人免疫缺陷病毒 (SHIV) 模型揭示了信封蛋白如何影响HIV-1病原性. 同受体使用 (CCR5与CXCR4) 在中决定了不同的CD4+T细胞损失模式,影响了疫苗开发.

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