阿尔多氨酸合成酶基因的多态性与左心室结构之间缺乏关联
H Schunkert1, C Hengstenberg, S R Holmer
1Klinik und Poliklinik für Innere Medizin II, University of Regensburg, Regensburg, Germany. heribert.schunkert@klinik.uni-regensburg.de
Circulation
|May 5, 1999
概括
在大型人群研究中,阿尔多合成酶-344C/T基因变异不会显著影响血清阿尔多水平,血压或左心室结构和功能. 这一发现表明,这种特定的遗传变异对心血管健康的临床相关性有限.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 心脏的生长和功能受到诸如阿尔多素之类的神经激素的影响.
- 阿尔多斯特刺激心脏肌细胞的生长和细胞外基质的积累.
- 一个特定的阿尔多合成酶基因变体 (-344C/T) 之前在一项小型研究中与左心室扩大有关.
研究的目的:
- 调查阿尔多氨酸合成酶-344C/T等位基因状态和心血管参数之间的关联.
- 在大量人群样本中检查这种遗传变异对血清阿尔多水平,血压和左心室结构和功能的影响.
主要方法:
- 利用来自两个大型基于人口的MONICA调查 (n=1445和n=562) 的数据.
- 进行了标准化的人类测量,心声回声和生化测量.
- 进行了阿尔多氨酸合成酶-344C/T等位基因状态的基因型定型.
主要成果:
- 没有发现阿尔多氨酸合成酶基因型与左心室壁厚度,尺寸,质量,缩功能或腹缩功能的心声测量之间的显著关联.
- 在阿尔多氨酸合成酶等位基因状态和血清阿尔多氨酸水平之间没有观察到显著的关联.
- 在样本和子组 (年龄,性别,药物使用) 中,结果一致.
结论:
- 在阿尔多合成酶基因中的位置-344的C/T交换不会显著影响血清阿尔多水平,血压或心脏大小/功能在被研究的白人群体中的变化.
- 这种变体与左心室异常之间之前提出的联系可能无法对更大,更多样化的群体进行概括.
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