绝经后的美国女性患有急性关节骨折的隐性维生素D缺乏症
M S LeBoff1, L Kohlmeier, S Hurwitz
1Department of Internal Medicine, Brigham and Women's Hospital, Boston, Mass 02115, USA. msleboff@bics.bwh.harvard.edu
JAMA
|May 5, 1999
概括
绝经后患有部骨折的女性往往缺乏维生素D,甲状腺上腺激素水平高. 解决维生素D缺乏症可能有助于预防未来的骨折并改善愈合.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 老年医学 老年医学
背景情况:
- 低维生素D水平与女性部骨折有关.
- 关于美国女性急性关节骨折的维生素D状况的数据有限.
研究的目的:
- 为了比较绝经后妇女的维生素D和副甲状腺激素水平,与那些接受选择性关节置换的女性相比.
- 评估急性部骨折住院妇女的维生素D状况.
主要方法:
- 一个比较的病例系列包括98名绝经后妇女 (30名关节骨折,68名选择性关节置换).
- 排除标准包括影响骨密度的疾病或药物.
- 主要测量的是25-氧维生素D和副甲状腺激素水平.
主要成果:
- 与非骨质疏松症和骨质疏松症选择性关节置换组相比,患有骨骨折的女性的25-氧维生素D水平显著降低.
- 与两组对照组相比,骨骨折的女性的副甲状腺激素水平显著更高.
- 50%的部骨折的女性缺乏维生素D水平 (<或=30.0nmol/L).
结论:
- 绝经后患有部骨折的女性经常表现出未被诊断的维生素D缺乏症.
- 维生素D补充和副甲状腺激素抑制可能会降低未来骨折的风险并有助于愈合.
- 提高对维生素D充足性的认识至关重要,尤其是在北度地区.
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