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Updated: Aug 3, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
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2种B血清组外膜蛋白脑膜炎球菌疫苗的免疫性:智利的一项随机对照试验

J W Tappero1, R Lagos, A M Ballesteros

  • 1Centers for Disease Control and Prevention, Meningitis and Special Pathogens Branch, Atlanta, GA 30333, USA. jwt0@cdc.gov

JAMA
|May 5, 1999
PubMed
概括

血清组B脑膜炎球菌疫苗在儿童和成年人中对同源菌株有效,但对异源流行菌株无效. 针对1类外膜蛋白 (OMP) 的流行病菌株特定疫苗在控制疫情方面表现有前途.

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Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...