激素替代疗法和乳腺癌高S期的激素替代疗法
M A Cobleigh1, F E Norlock, D M Oleske
1Section of Medical Oncology, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill 60612, USA.
JAMA
|May 5, 1999
概括
绝经后的激素替代疗法 (HRT) 使用似乎刺激雌激素受体阳性乳腺癌的生长,由较高的S相分数表明. 对ER阴性瘤和预后的影响尚不清楚.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 癌症生物学 癌症生物学
背景情况:
- 长期的绝经后激素替代疗法 (HRT) 与乳腺癌发病率增加和死亡率降低有关.
- 这种差异的生物学基础需要调查.
研究的目的:
- 为了比较HRT使用者与从未使用者的乳腺癌预后特征.
- 为了研究HRT对瘤细胞增殖的影响.
主要方法:
- 前性队列研究 (1989-1996) 涉及331名绝经后妇女,349名女性患有侵袭性乳腺癌.
- 对当前HRT使用者的雌激素受体 (ER) 状态和S相分量的分析,与从未使用者相比.
主要成果:
- HRT使用者显示高S相分数的频率显著更高 (OR,2.82).
- 这种增加主要观察到ER阳性癌症 (OR,5.25),而不是ER阴性癌症 (OR,1.08).
结论:
- 使用HRT可能会刺激ER阳性乳腺癌的生长,如S相分数所示.
- 对于ER阳性瘤的HRT使用者的预后影响目前尚不清楚.
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