对叶酸摄入量和乳腺癌风险的前性研究
S Zhang1, D J Hunter, S E Hankinson
1Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA. Shumin.Zhang@channing.harvard.edu
JAMA
|May 11, 1999
概括
充足的叶酸摄入量可以减少与饮酒相关的乳腺癌风险增加. 较高的叶酸水平与饮酒女性的风险降低45%有关,这表明有保护作用.
科学领域:
- 营养流行病学 营养流行病学
- 预防癌症 预防癌症
- 公共卫生 公共卫生
背景情况:
- 叶酸对于DNA合成和甲基化至关重要.
- 叶酸摄入量可能会影响乳腺癌风险,尤其是在饮酒时.
研究的目的:
- 检查叶酸摄入量与乳腺癌风险之间的联系.
- 为了确定更高的叶酸摄入量是否能减轻与酒精有关的乳腺癌风险.
主要方法:
- 来自护士健康研究的88,818名女性的前性队列研究 (1980-1996).
- 根据叶酸和酒精摄入水平评估乳腺癌发病率.
主要成果:
- 总叶酸摄入量与整体乳腺癌风险没有关联.
- 在每天饮用≥15克酒精的女性中,高叶酸摄入量 (≥600微克/天) 将乳腺癌风险降低了45% (RR=0.55).
- 低叶酸摄入量 (<300微克/天) 的女性酒精风险最高.
结论:
- 足够的叶酸摄入量似乎可以降低与饮酒相关的乳腺癌风险.
- 这凸显了叶酸状况在缓解酒精致癌效应方面的重要性.
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