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相关概念视频

Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...

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相关实验视频

Updated: Jul 8, 2026

Quantitative Comparison of cis-Regulatory Element (CRE) Activities in Transgenic Drosophila melanogaster
08:19

Quantitative Comparison of cis-Regulatory Element (CRE) Activities in Transgenic Drosophila melanogaster

Published on: December 19, 2011

一个控制Drosophila细分的基因复合体.

E B Lewis

    Nature
    |December 7, 1978
    PubMed
    概括

    比索拉克斯基因复合体调节了昆虫的发育. 基因抑制梯度受到cis-regulatory元素和Polycomb抑制剂的影响,控制Drosophila的胸部和腹部细分模式.

    科学领域:

    • 发展生物学 发展生物学
    • 遗传学 是一个遗传学.
    • 分子生物学分子生物学

    背景情况:

    • 德洛索菲拉的 bithorax 基因复合体对于胸部和腹部发育至关重要.
    • 这个复合体包括至少八个参与发育模式的基因.

    研究的目的:

    • 为了研究控制 bithorax 基因复合物的调控机制.
    • 了解cis调节元素和Polycomb位点在基因抑制和细分模式中的作用.

    主要方法:

    • 在 bithorax 综合体内对基因抑制状态的分析.
    • 检查控制基因表达的cis-regulatory元素.
    • 调查Polycomb位点作为抑制器的功能.

    主要成果:

    • 在 bithorax 综合体内,至少有四个基因受到 cis 调节元件的调节.
    • 在Polycomb位置似乎编码一个抑制器的 bithorax复合体.
    • 观察到的野生类型和突变分子细分模式与预测的抑制剂梯度相关.

    结论:

    • 抑制剂度的前后梯度沿胚胎,以及沿染色体的cis-regulatory元素亲缘关系的近距离梯度解释了细分模式.

    更多相关视频

    Recombineering Homologous Recombination Constructs in Drosophila
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    Recombineering Homologous Recombination Constructs in Drosophila

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    Embryo Microinjection for Transgenesis in Drosophila

    Published on: June 7, 2024

    相关实验视频

    Last Updated: Jul 8, 2026

    Quantitative Comparison of cis-Regulatory Element (CRE) Activities in Transgenic Drosophila melanogaster
    08:19

    Quantitative Comparison of cis-Regulatory Element (CRE) Activities in Transgenic Drosophila melanogaster

    Published on: December 19, 2011

    Recombineering Homologous Recombination Constructs in Drosophila
    14:23

    Recombineering Homologous Recombination Constructs in Drosophila

    Published on: July 13, 2013

    Embryo Microinjection for Transgenesis in Drosophila
    05:32

    Embryo Microinjection for Transgenesis in Drosophila

    Published on: June 7, 2024

  • 这些发现阐明了Drosophila体平面形成的复杂遗传控制.