相关实验视频

Updated: Aug 2, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

自动边界检测可以识别患有恶性瘤的儿童的亚临床 antrcycline 心脏毒性

I Hashimoto¹, F Ichida, M Miura

¹Department of Pediatrics, First Division of Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.

|May 11, 1999

概括

自动边界检测 (ABD) 可以识别在接受 antracycline 化疗的儿童中的亚临床心脏损伤,即使标准心声图显示正常功能. 这种敏感的方法可以检测到心脏毒性的早期迹象.

科学领域:

心脏病学心脏病学
儿科瘤学儿科瘤学
医疗成像医学成像

背景情况:

抗环素化疗可以导致心肌功能障碍的儿童,即使在低剂量.
早期发现心脏毒性对于管理治疗和预防长期心脏损伤至关重要.

研究的目的:

评估自动边界检测 (ABD) 对于在无症状儿童中识别潜在心肌损伤的临床有用性.
评估ABD是否可以揭露亚临床 antrracycline诱导的心脏毒性.

主要方法:

研究了34名正在接受或已经完成了环素化疗的儿童 (化疗组) 和40名健康儿童 (对照组).
所有参与者都接受了综合性心声回声,包括M模式,多普勒和自动边界检测 (ABD).
在使用常规心声学和ABD的组之间比较左心室功能参数.

主要成果:

传统的心声回声扫描显示,两组之间喷射分数或传导流速没有显著差异.
与对照组相比,自动边界检测 (ABD) 显示化学疗法组的峰值填充率显著降低 (P<0.0001) 和达到峰值填充率的时间延长 (P<0.0001).
这些发现表明,在接受过 antracyclines 治疗的儿童中,心肌损伤可能是亚临床的.

结论:

声心谱ABD是一种敏感且有价值的非侵入性工具,用于评估儿童的亚临床人环素心脏毒性.
而ABD可以检测到常规心声学方法所遗漏的心脏损伤的早期迹象.

更多相关视频

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [¹⁸F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

相关概念视频

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...